Evolved 2025 is a global hackathon initiative to accelerate AI breakthroughs in healthcare and life sciences. The 10-day Global Sprint is open to any startups working under one of three broad Challenges, and successful applicants are provided full access to multiple GPUs from Nebius as well as state-of-the-art models from NVIDIA. Winning teams will be invited to NVIDIA headquarters to showcase their work. Prior to the sprint, regional hackathons to spark new projects and teams for each challenge will run in-person in Boston, Berlin, and San Francisco.
2025 CHALLENGES
Agentic Automation and Workflow Optimization
AI systems that act in collaboration with scientists, engineers, or clinicians to accelerate work across research, development, and operations. Projects may involve intelligent agents, workflow orchestrators, or documentation tools that reduce manual effort, improve process efficiency, and enable new levels of scale or speed in biotech and clinical settings. The emphasis is on AI that executes tasks, coordinates complex workflows, or supports end-to-end decision execution.
Example Projects:
Agentic copilots for experimental design, literature-grounded result interpretation, or lab decision-making
AI platforms that orchestrate multi-step R&D workflows, such as smart LIMS or integrated lab data pipelines
Automated systems for drafting and managing clinical trial protocols, regulatory filings, or scientific reports
Integrative Intelligence for Biomedicine
Models that integrate diverse biomedical data to improve representation, inference, and prediction in complex biological systems. Projects may involve fine-tuning foundation models for biological tasks, constructing multimodal embeddings, or linking structured and unstructured biomedical knowledge into unified architectures.
Example Projects:
Multimodal models that combine omics, imaging, and clinical features to improve disease classification or patient stratification
Fine-tuned foundation models trained on biomedical corpora to extract molecular or clinical insights
Knowledge graph-augmented models that encode biological relationships for target prioritization or mechanism prediction
Genomic Modeling and Molecular Optimization
Methods for modeling biological sequences and molecular structures, working with data at the genomic, transcriptomic, or protein level. Applications may span early-stage discovery to molecular engineering, including target identification, variant interpretation, or therapeutic molecule design.
Binder Design Challenge
Develop a binder that is cross-reactive for a human receptor and a mouse receptor in the same family. Target receptors will be announced at the start of the sprint, on November 7th. Submitted binders will be screened by Adaptyv Bio, and the top three designs will receive Adaptyv Bio lab credits!
Example Projects:
Identify and refine genomic regions (e.g., UTRs, enhancers, non-coding RNAs) that influence target binding or expression
Engineering proteins or antibodies for cross-species reactivity, reduced immunogenicity, or enhanced stability
Designing synthetic nucleotides or viral sequences for targeted delivery or gene modulation
REGIONAL HACKATHONS
October 2025
In-person hackathons uniting technical and scientific talent with computational resources to spark rapid innovation in directed by specific prompts within a challenge theme. Promising projects and teams are invited to apply to the Global Sprint to accelerate their work.
Open to engineers, researchers, scientists, and students eager to tackle pressing AIxBio challenges. For technical applicants, prior experience building and training AI models is recommended. Scientist applicants should have deep knowledge in the scientific application space of interest. Applicants are not required to apply with a pre-existing team or project.
GLOBAL SPRINT
November 7 - November 16, 2025
A 10-day virtual sprint hackathon providing full access to GPUs and state of the art pre-trained models to accelerate highly promising projects, judged by industry leaders and Evolved 2025 partners.
Open to existing startups and teams with early stage ideas and project proposals. Have a project but need teammates? Join our community slack space this summer to make your pitch and find a cofounder.
Available models and datasets will be announced throughout the summer and early fall. Stay tuned!